Postdoctoral position at Minneapolis, MN, USA
A 2-3 year post-doctoral position is available at the University of Minnesota, Minneapolis.
Our lab is interested in molecular mechanisms that regulate two types of embryonic progenitor populations. One is "limb progenitors" which are specified from a small group of cells in the lateral plate mesoderm and will undergo patterning and morphogenesis to form functional limbs. The other is bi-potential "neuromesodermal progenitors" that fuel body elongation and contribute to both the neural tube and somite in post-gastrulation embryos. We use mice and zebrafish to study molecular, cellular and genetic mechanisms that regulate these progenitors for normal body development.
We are looking for a smart and self-motivated person. We have recently generated transgenic and CRISPR mutant zebrafish lines, so experience in the zebrafish system and imaging is a plus.
Our laboratory is located in the Developmental Biology Center, and has close interaction with laboratories in the Stem Cell Institute at the University of Minnesota. Interaction with other groups within the University will also be available, and could allow for assistance with projects that extend beyond our lab's main area of focus.
Prospective candidates should contact
Yasu Kawakami, Ph.D. (firstname.lastname@example.org).
Department of Genetics, Cell Biology and Development, University of Minnesota
Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos.
Tahara N, Kawakami H, Chen K, Anderson A, Peterson MY, Gong W, Shah P, Hayashi S, Nishinakamura R, Nakagawa Y, Garry DJ, and Kawakami Y.
Development, In press
Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules.
Tahara N, Akiyama R, Theisen JWM, Kawakami H, Wong J, Garry DJ, and Kawakami Y.
Dev Biol. 2018; 434(1):74-83.
Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements.
Akiyama R, Kawakami H, Wong J, Oishi I, Nishinakamura R, Kawakami Y.
Proc Natl Acad Sci U S A. 2015;112(16):5075-80.